Recent advances in the understanding of ra etiology and pathogenesis suggest that prevention of ra onset in at risk individuals may be an attainable goal this themed issue of clinical therapeutics features expert perspectives on the opportunities challenges and progress toward development of preventive approaches for ra. Vols 1 2 consist chiefly of papers presented at the 3rd 4th annual symposium on recent advances in clinical therapeutics antivirals and antimicrobials anticancer agents and cardiovascular therapy series title antivirals and antimicrobials anticancer agents . Filociclovir mbx 400 cyclopropavir is an antiviral agent with activity against cytomegalovirus cmv a phase 1 double blind randomized placebo controlled 31 ratio single center multiple ascending dose trial was conducted to assess the safety tolerability and pharmacokinetics of filociclovir. It is not an easy task to describe the advances in clinical pharmacology and therapeutics over the past year i will start with the general issue of cost effective prescribing which has moved up the political agenda in britain after the publication of two influential reports
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