Background dopamine d 2 receptor and dopamine transporter availability in the striatum have each been reported abnormal in generalized social anxiety disorder gsad in studies using single photon computerized tomography spect d 2 receptors and dopamine transporters have not previously been studied within the same gsad subjects however and prior gsad studies have not assessed dopamine . Image by nida cocaine in the brain in the normal neural communication process dopamine is released by a neuron into the synapse where it can bind to dopamine receptors on neighboring neurons normally dopamine is then recycled back into the transmitting neuron by a specialized protein called the dopamine transporter if cocaine is present it attaches to the dopamine transporter and blocks . Dopamine receptors are the areas of the brain that accept the message delivered via the dopamine system and ended by the dopamine transporters certain neurons are sensitive to dopamine and these are the ones that receive the dopamine transmissions what are dopamine transporters dopamine transporter is a protein existing between the neurons . Dopamine transporter gene dat1 slc6a3 the dopamine transporter gene slc6a3 or dat1 encodes a protein involved in two key functions 1 release of dopamine into the synapse to activate neurotransmitter receptors and 2 reuptake of dopamine into presynaptic neurons to terminate the signal the former process is stimulated by amphetamines
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